Association of Host Interferon-<i>γ</i> Gene Polymorphism with <i>Toxoplasma gondii</i> Infection in Pregnant Women of Bangladesh

Human toxoplasmosis is caused by the intracellular protozoan parasite Toxoplasma gondii. Although T. gondii infection generally asymptomatic for most of immunocompetent adults, severe complications may occur particularly in pregnant women and immunocompromised individual. Host cell immunity plays a critical role differentiation persistence host. Therefore, genetic polymorphism host immune genes, instance interferon-γ gene could be linked with possibility infection. The objective study was to verify link between single nucleotide polymorphisms (SNPs) IFN-γ through correlating anthropometric sociodemographic parameters. In this study, ninety-two (N = 92) (16 - 40 years) healthy controls 95) similar age ranges were included. Among them, 25% (n 23) seropositive IgG antibodies Rapid Test Assay. Allelic genotypic frequencies +874T/A (rs2430561) SNPs evaluated using ARMS-PCR. distribution A T alleles specific position gondii-infected control groups did not differ significantly, according data. However, we found higher frequency (13.04%) A/A genotype infected as compared non-infected individuals (8.70%), demonstrating that susceptibility increased homozygosity allele. Further studies are needed find out Bangladesh.